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Functional esophageal disorders / Functional dysphagiaTreatment is initially directed to reassurance, avoidance of precipitating factors, careful mastication of food, modification of any psychological abnormalities that may be directly relevant to symptom production(1), and management of underlying motility abnormalities, if present(2). ]
Antireflux therapy(2), antidepressants and psychotherapy(1) can be all attempted. Smooth muscle relaxants, botulinum toxin injection, or even pneumatic dilation may be useful in some patients with spastic disorders, particularly if incomplete lower esophageal sphincter relaxation and delayed distal esophageal emptying on barium radiography are evident(1).
In patients with functional dysphagia, both abnormal motor events and abnormal perception may contribute to enhance the symptoms, but limited data are available to support this hypothesis. Loss or reduction in the peristaltic response to swallowed food boluses may be relevant in some subjects(14). Moreover, dysphagia also can be induced by intraluminal acid and balloon distension, suggesting that abnormal esophageal sensory perception may be a causal factor as well(15).
Anecdotal information indicates that mental disorders - especially anxiety, depression - and psychosomatic conditions are significantly more common in patients with functional dysphagia than in patients in whom other explanations for their symptoms are more convincing(2). Acute stress experiments suggest that central factors can precipitate motor abnormalities potentially responsible for dysphagia(3). Barium transit is adversely altered in both asymptomatic and symptomatic subjects during recollection of unpleasant topics or stressful, unpleasant interviews. Noxious auditory stimuli or difficult cognitive tasks have noted to alter manometric recordings by increasing contraction wave amplitude and occasionally inducing simultaneous contraction sequences. Still the relevance of these findings to functional dysphagia remains conjectural(1).
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