- Basic concepts
- Functional esophageal disorders
- Functional gastroduodenal disorders
- General approach to gastroduodenal disorders
- Functional dyspepsia
- Belching disorders
- Nausea and vomiting disorders
- Functional bowel disorders
- Scientific update
- Resources
- Bibliography
Search
Functional bowel disorders / Present in the treatment of IBS
Present in the treatment of IBS
The eight placebo-controlled trials with probiotics in IBS are listed in the next table.
VSL#3, bifidobacteria (B. longum, B. infantis, B. breve); lactobacilli (L. acidophilus, L. casei, L. bulgaricus, L. plantarum); Streptococcus salivarius subspecies termophilus.
Clinical studies will be crucial to set clear guidelines for the use of probiotics in IBS. Larger clinical studies using specific probiotic strains are needed. Ideally, these studies should apply probiotic strains with known therapeutic targets previously determined in animal models and should include symptom and quality of life assessments as well as objective markers of intestinal immune activation and gut function.
Basic research in the area of probiotics and IBS will be useful in identifying potential probiotic strains and gastrointestinal targets.]
11. Verdu E.F., Bercik P, Bergonzelli GE. Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction. Gastroenterology 2004; 127:82
12. Verdu E.F., Bercik P, Bergonzelli G. Lactobacillus paracasei normalizes post-infective dysmotility in vivo and induces a sustained attenuation of inflammatory mediators. Gastroenterology 2004; 126 (suppl 2): A170.
13. O'Mahony L., McCarthy J, Kelly P. Lactobacilli and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005; 128 (3): 541-551.
14. Balsari A, Ceccarelli A, Dubini F. The fecal microbial population in the irritable bowel syndrome. Microbiologica 1982; 5: 185-194.
15. Kamm K, Hoppe S, Breves G. Effects of the probiotic yeast Saccharomyces boulardii on the neurochemistry of myenteric neurons in pig jejunum. Neurogastroenterol Motil 2004; 16: 53-60.
16. Verdu E.F., Bercik P, Verma-Gandhu M. Specific probiotic therapy attenuates antibiotic-induced visceral hypersensivity in mice. Gut 2005 (Epub ahead of print).
1 - 2