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Activia
Effects of a milk fermented with Bifidobacterium lactis DN-173 010 on colonic transit time in healthy adults(8)
Bouvier et al. published in 2001 the results of a randomized, controlled, double-blind, parallel study including 72 healthy adult volunteers (mean age 30 years). They demonstrated that the ingestion during 11 days of a fermented milk (3x125 g/day) containing the strain Bifidobacterium lactis DN-173 010 significantly reduces total colonic transit time by 21% and sigmoid transit time by 39%, compared to an identical fermented milk (3x125 g/day) in which bacteria were killed by heat treatment. The improvement in total colonic transit time was significant in both men (p<0.03) and women (p<0.05), and the effect on sigmoid colon was seen particularly in women. These beneficial effects were not found with the heat-treated product, suggesting that both probiotic survival and/or metabolic activity are necessary.
Effect of ACTIVIA® on colonic transit time in women(9)
Marteau et al. (2002) performed a randomized, controlled, double-blind, cross-over study including 32 healthy women (mean age 27 years) comparing the efficacy of ACTIVIA® (3x125 g/day) with a fermented milk preparation without bifidobacteria, during a consumption period of 10 days. Total colonic and sigmoid transit times were significantly shortened (p<0.05) with ACTIVIA® versus control (51.5 +/- 30.2 hours vs. 60.7 +/- 27.1; sigmoid: 21.6 +/- 14.9 hours vs. 26.8 +/- 14.2). In women with an initial colonic transit time of more than 40 hours, the sigmoid and total colonic transit time were significantly shorter following consumption of ACTIVIA® versus control group and the baseline values recorded prior to consumption.
ACTIVIA® is a fermented milk that contains a specific probiotic culture, scientifically known as Bifidobacterium animalis subspecies lactis DN-173 010*, that has clinically been proven to survive the passage through the entire gastrointestinal tract and whose daily consumption improves slow intestinal transit, particularly in women and in the elderly. ACTIVIA® has also demonstrated a positive effect on the improvement of digestive comfort in subjects with digestive complaints.
Clinically proven to survive in the GI Tract]
ACTIVIA® contains Bifidobacterium lactis DN-173 010, which was clinically proven to survive the passage through the gastrointestinal tract.
Various human studies have been performed to determine the survival of Bifidobacterium lactis DN-173 010 in the gastrointestinal tract(1 to 7).
- Bifidobacterium lactis DN-173 010 survived successfully (105 -106cfu/g) for at least 90 minutes in the stomach, while another commercial strain was much less resistant. The shelf life of the product does not affect the survival capability of Bifidobacterium lactis DN-173 010.(1)
- Bifidobacterium lactis DN-173 010 survived passage through the small intestine. After 8 hours, 109 cfu of the strain were recovered in the terminal ileum.(2)
- Bifidobacterium lactis DN-173 010 survived passage through the entire gastrointestinal tract and was recovered alive and in large quantities in stools (108 to 109 cfu/g). (3 to 7)
Clinical Evidence on transit time]
Positive effect of ACTIVIA® or Bifidobacterium lactis DN-173 010 on reduction of transit time has been demonstrated in 4 clinical studies using appropriate designs and methods(8 to 11). These studies have been performed in healthy adults or elderly of both sexes with normal to slow transit. Coloured markers were used to determine total (oro-faecal) transit time and radio-opaque pellets to measure colonic transit time.
Two clinical studies assessed the effect of ACTIVIA® or a fermented milk with Bifidobacterium lactis DN-173 010 on colonic transit time(8,9). And two clinical studies have been performed to assess the effect of ACTIVIA® consumption on total transit time(10,11).
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